Scientific Journal of Medical Faculty of Halu Oleo University

Correlation between Knowledge and Attitudes with Malaria Prevention Practices in the Working Area of the Kabawo Public Health Center

Sun, 24 Mar 2024 00:00:00 +0000

Background: Malaria is still one of the public health problems in Southeast Sulawesi Province. Annual Parasite Incidence (API) in the work area of Kabawo Primary Health Center was 48.90‰ in 2016. Limited public knowledge is an essential determinant of the emergence of malaria and influences community participation in malaria prevention programs. Research Purpose: This research aims to determine the relationship between knowledge and behavior in malaria prevention practices in the work area of Kabawo Primary Health Center. Research Methods: This research was an observational analytic design using a cross-sectional approach. The dependent variable in this research was malaria prevention practice, and the independent variable was knowledge and behavior. The research location was in the Kabawo Primary Health Center's working area, with 56 respondents using the total sampling method. Data was obtained by filling out the knowledge questionnaires, behaviors and practices, and interviews. Data analysis used a spearman rank statistical test with a p-value <0.05 and contingency coefficient (r-value). Research Result: The result of this research of 56 respondents found 22 respondents (39.3%) had good knowledge, good behavior, and good prevention practices, as many as 12 respondents (21.4%) had good knowledge, good behavior, and less of prevention practices, as many as 22 respondents (39,3%) have less knowledge, less behavior and less of prevention practices. Based on the results of the Spearman rank statistical test analysis, it was found that the knowledge and behaviors with malaria prevention practices showed the p-value of 0,000 <0,05 with the value r = 0,647. Conclusion: This research concluded that there was a relationship between knowledge and behaviors to prevention practices in the work area of Kabawo Primary Health Center and had a strong correlation between variables with a positive correlation direction, meaning that the better knowledge and behaviors, the better prevention practices.

Advanced Glycation End-Product (AGEs) Level in a Diabetic Rat Model Treated with Warfarin Anticoagulant

Musyarrafah Musyarrafah, Wanadiatri Halia, I Gede Angga Adnyana — Sun, 24 Mar 2024 00:00:00 +0000

Background: Diabetes mellitus is a chronic disease that is the most seriously cause of macrovascular and microvascular complications that threaten life , expensive and reduces life expectancy. The occurence of cell damage and inflammation due to AGEs and RAGE reactions generally exacerbates the risk of macrovascular complications . Pharmacological therapy given to prevent these complications is the warfarin anticoagulant . the duration of warfarin use can increase the hardening of blood vessels or vascular calcification and is compounded by AGEs accumulation and RAGE activation. Objective: To analyze plasma AGE levels as a risk factor for vascular calcification in DM and non-DM rats models treated with warfarin anticoagulants. Method: This study used a Quasi experimental method with a posttest only control group design. The total sample was 28 samples divided into 4 groups, each group consisting of 7 rats grouped into DM + Aquadest group, DM + Warfarin group, non-DM + Aquadest group , and non-DM + Warfarin group. Plasma AGE levels were measured using the ELISA method and the results were analyzed using Anova. Results: AGE Level in the DM + Warfarin group (Mean= 1.183; SD=0.16) was slightly high than AGE level in normal rat group with Warfarin induction (Mean=1,012; SD=0,02). In the normal rat group treated with Aquadest was slightly low than AGE level in the DM rat group with warfarin induction (Mean=1.147; SD=0.13). Interestingly, There was no difference in plasma AGE levels between groups (p=0,155). Conclusion: AGE levels at the onset of DM are not yet able to progressively activate vascular damage through the AGE/RAGE signaling pathway.

The Impact of Carbonated Sodium Bicarbonate Drinks on Physical Fitness in Adolescents

Sun, 24 Mar 2024 00:00:00 +0000

Background: Physical fitness is a crucial factor for individuals to support their daily physical activities. Soda beverages have gained popularity among adolescents and are believed to affect physical fitness. Objective: This study investigated the influence of soda consumption on the physical fitness of adolescents. Methods: The study included 30 male participants with 18-25 years old who voluntarily participated and willingly provided informed consent. Physical fitness was measured before and after carbonated sodium bicarbonate drinks consumption using the Harvard Step Test. Participants orally consumed NaHCO₃ at a dose of 0.3 gr/kg of body weight in carbonated water at a dose of 0.4 ml/kg of body weight. The employed statistical test was the T-test. Results: The average physical fitness score of the participants before soda consumption was 34.37 ± 13.465, while the average score after soda consumption was 51.57 ± 20.100. The T-test yielded a score of 0.001. Conclusion: Based on the statistical analysis, it can be concluded that carbonated sodium bicarbonate drinks can enhance physical fitness in adolescents.

Diagnosing Performance of Matrix Metalloproteinase-9 (MMP-9) and Alberta Stroke Program Early CT Score (ASPECTS) as The Clinical Degree Predictor of Ischemic Stroke: Which One is Better ?

Ashaeryanto, Akbar, Iqbal, Gita, Ashari, Cahyono — Sun, 24 Mar 2024 00:00:00 +0000

Background: Matrix metalloproteinase-9 (MMP-9) and Alberta Stroke Program Early CT Score (ASPECTS) are predictors of the ischemic stroke clinical degree. A marker with good performance is needed to estimate the clinical degree following an ischemic stroke attack. Puropose(s): Analyze the comparison of MMP-9 levels with ASPECTS as a predictor of the clinical degree of ischemic stroke. Methods: Analytical study with a prospective cohort design. This study sample consisted of middle cerebral artery ischemic stroke patients at RSUP Dr. Wahidin Sudirohusodo and Network Hospital with a total of 32 patients. The MMP-9 level was measured by using the ELISA method, while ASPECT was assessed based on the head CT scan. Clinical degree assessment according to the National Institute of Health Stroke Scale (NIHSS). Spearman and Receiver Operating Characteristic (ROC) tests were performed to determine sensitivity and specificity. Results: ASPECTS sensitivity and specificity values on NIHSS admission: 85.71% and 90.91%, NIHSS day 14: 70.37% and 100%. Sensitivity and specificity of MMP-9 on NIHSS admission: 72.73% and 76.19%, NIHSS day 14: 100% and 70.73%. Conclusion: ASPECTS has a stronger specificity level than MMP-9 as a predictor of the pure clinical degree of ischemic stroke, and MMP-9 has a stronger sensitivity value than ASPECTS as a predictor pure clinical degree day 14.

Accuracy of Multiparametric Magnetic Resonance Imaging (MRI) in Determining Prostate Malignancy Based on Histopathological Results

Sun, 24 Mar 2024 00:00:00 +0000

Background: Prostate cancer is the most common malignancy in men in many regions of the world and is the second cause of cancer death in men as well as the third most common urological cancer in Indonesian men. One of the radiology examinations used to detect prostate cancer is multiparametric MRI which is a series of prostate magnetic resonance combining anatomical and functional imaging to detect and characterize prostate lesions. Purposes: This study aims to assess the accuracy of multiparametric prostate MRI in detecting prostate cancer based on the results of histopathological examination. Methods: This research used sensitivity value, specificity value, positive prediction value, and negative prediction value as well as Chi-Square test (P value < 0.05) to assess accuracy in SPSS program version 25. Results: This research was conducted at the central radiology installation of Dr. Wahidin Sudirohusodo Hospital and Hasanuddin University Hospital Makassar from February 2022 to July 2022, with 40 samples were obtained. Most samples were at the age of 60-70 years with 18 samples (45%), the most common lesion site was in the transitional zone with 19 samples (47.5%), multiparametric MRI results were predominant in the PIRADS 2 group with total sample of 18 (45%), PIRADS grading was obtained from benign categories (PIRADS 1 and 2) as much as 18 samples (45%) and from malignancy categories (PIRADS 3-5) with 22 samples (55%). Histopathological examination obtained benign results (BPH and prostatitis) in 21 samples (52.50%) and malignant in 19 samples (47.5%). Conclusion: We found correlation between multiparametric prostate MRI dan histopathological results by using bivariate correlation test with p values < 0.001. Multiparametric prostate MRI sensitivity value 100%, specificity 85.7%, positive prediction value 83.3%, Negative Prediction Value 100%, and accuracy 92.5%.